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OSI 420 - Erlotinib, 6-O-Desmethyl-

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Axon 1632 CAS [183321-86-0] MF C21H21N3O4MW 379.41 Purity: 98% Soluble in DMSO Description An active O-desmethyl metabolite of Erlotinib (Axon 1128), which inhibits EGFR tyrosine kinase; precursor of [11C]-labelled Erlotinib for PET study References Certificates Categories Extra info A Broniscer et al.?Plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite OSI-420. Clin. Cancer Res. 2007, 13(5), 1511-1515. ? Y Togashi et al. Cerebrospinal Fluid Concentration of Erlotinib and its Active Metabolite OSI-420 in Patients with Central Nervous System Metastases of Non-small Cell Lung Cancer. J. Thoracic Oncol. 2010, 5(7),?950-955. ? I. Bahce et al. Development of [(11)C]erlotinib positron emission tomography for in vivo evaluation of EGF receptor mutational status. Clin. Cancer Res. 2013, 19, 183-193. ? NF Smith et al. Modulation of erlotinib pharmacokinetics in mice by a novel cytochromeP450 3A4 inhibitor, BAS 100. Br.?J. Cancer 2008, 98, 1630–1632. ? AA Memon et al. Positron Emission Tomography (PET) Imaging with [11C]-Labeled Erlotinib: A Micro-PET Study on Mice with Lung Tumor Xenografts. Cancer Res. 2009, 69(3), 873-878. Certificate of Analysis Material Safety Data Sheet Angiogenesis Cell Signaling & Oncology EGFR JAK-STAT RTK class I; EC 2.7.10.1 EGFR tyrosine kinase inhibitor Chemical name 2-(4-(3-ethynylphenylamino)-7-(2-methoxyethoxy)quinazolin-6-yloxy)ethanol Parent CAS No. [183321-86-0] Order Size Unit Price Stock 2 mg €90.00 In Stock

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現(xiàn)貨詢價(jià)，電話：010-67529703

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axonmedchem

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