產(chǎn)品名稱 Defactinib - VS 6063 | PF 04554878
產(chǎn)品貨號 Axon 2574 CAS [1073154-85-4] MF C20H21F3N8O3SMW 510.49 Purity: 98% Soluble in DMSO Description Orally available second-generation inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase-2 (PYK2) with an acceptable safety profile in clinical trials (IC50 values 0.6 nM for each kinase, and >100-fold greater selectivity for FAK and PYK2 than for other, non-target kinases). Structurally closely related to PF 431396 (Axon 2107). KEYWORDS: Defactinib | supplier | FAK/PYK2 inhibitor | VS 6063 | PF 04554878 | PF04554878 | VS6063 | PF4554878 | CAS [1073154-85-4] | [1073160-26-5] | Phosphorylation | FAK | PYK2 | Inhibitor | focal adhesion kinase | proline-rich tyrosine kinase-2 | solid | tumor | malignancies | prostate cancer
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Defactinib - VS 6063 | PF 04554878

Based on 120 reference(s) in Google Scholar 10 10 120

Axon 2574

CAS [1073154-85-4]

MF C20H21F3N8O3S
MW 510.49

  • Purity: 98%
  • Soluble in DMSO

Defactinib

Description

Orally available second-generation inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase-2 (PYK2) with an acceptable safety profile in clinical trials (IC50 values 0.6 nM for each kinase, and >100-fold greater selectivity for FAK and PYK2 than for other, non-target kinases). Structurally closely related to PF 431396 (Axon 2107).

KEYWORDS: Defactinib | supplier | FAK/PYK2 inhibitor | VS 6063 | PF 04554878 | PF04554878 | VS6063 | PF4554878 | CAS [1073154-85-4] | [1073160-26-5] | Phosphorylation | FAK | PYK2 | Inhibitor | focal adhesion kinase | proline-rich tyrosine kinase-2 | solid | tumor | malignancies | prostate cancer
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