產(chǎn)品名稱

HS666 hydrochloride

產(chǎn)品貨號(hào)

Axon 2781 CAS [1409931-99-2] MF C20H25NO.HClMW 331.88 Purity: 99% Soluble in DMSO Description HS666 is a selective κ opioid receptor partial agonist (Ki value of 5.9 nM) which activates central κ receptors to produce potent antinociception. Moreover, HS666 displays pharmacological characteristics of a κ receptor analgesic with reduced liability for aversive effects correlating with its low efficacy in the β-arrestin2 signalling pathway. Keywords: HS666 hydrochloride | supplier | Kappa-opioid partial agonist | HS 666 hydrochloride | HS-666 hydrochloride | CAS [1409931-99-2] | [1409931-91-4] | Opioids | OPR-κ | Partial agonist | Receptors | Antinociception

產(chǎn)品價(jià)格

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產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

HS666 hydrochloride

Based on 4 reference(s) in Google Scholar 8 10 4

Axon 2781

CAS [1409931-99-2]

MF C20H25NO.HCl
MW 331.88

Purity: 99%
Soluble in DMSO

HS666 hydrochloride

Description

HS666 is a selective κ opioid receptor partial agonist (Ki value of 5.9 nM) which activates central κ receptors to produce potent antinociception. Moreover, HS666 displays pharmacological characteristics of a κ receptor analgesic with reduced liability for aversive effects correlating with its low efficacy in the β-arrestin2 signalling pathway.

M Spetea et al. Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. J Med Chem. 2012 Nov 26;55(22):10302-6.

M Spetea et al. Selective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice. Br J Pharmacol. 2017 Aug;174(15):2444-2456.

Certificate of Analysis
Material Safety Data Sheet

Cardiovascular CNS Pain & Inflammation Endocrinology OPR-κ A4

Kappa-opioid partial agonist

Chemical name

3-(2-((Cyclopropylmethyl)(phenethyl)amino)ethyl)phenol hydrochloride

Parent CAS No.

[1409931-91-4]

產(chǎn)品資料