| 產(chǎn)品名稱 | AMG 837 calcium salt |
| 產(chǎn)品貨號 | Axon 2405 CAS [1291087-14-3] MF C26H20F3O3.?CaMW 457.47 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Orally bioavailable partial agonist of the GPR40 (EC50 value 13.5 nM for AMG 837 stimulated Ca2+ flux in CHO cells expressing human GPR40) with a superior pharmacokinetic profile. AMG837 stimulated robust glucose-dependent insulin secretion (EC50 value 142±20 nM) in isolated rodent islets, and lowered post-prandial glucose in normal rats. AMG-837 exhibits a potential utility for the treatment of type 2 diabetes. References Certificates Categories Extra info D.C. Lin et al. AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents. PLoS One. 2011;6(11):e27270. ? J.B. Houze et al. AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1267-70. ? J. Luo et al. A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents. PLoS One. 2012;7(10):e46300. ? Y.J. Choi et al. G-protein coupled receptor 40 agonists as novel therapeutics for type 2 diabetes. Arch Pharm Res. 2014 Apr;37(4):435-9. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Diabetes & Metabolism GPR40 A11 Orally bioavailable partial agonist of GPR40 (FFA1) Chemical name (S)-3-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)phenyl)hex-4-ynoic acid calcium salt Parent CAS No. [865231-46-5] Order Size Unit Price Stock 5 mg €110.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
AMG 837 calcium saltAxon 2405 CAS [1291087-14-3] MF C26H20F3O3.?Ca
Description
Orally bioavailable partial agonist of the GPR40 (EC50 value 13.5 nM for AMG 837 stimulated Ca2+ flux in CHO cells expressing human GPR40) with a superior pharmacokinetic profile. AMG837 stimulated robust glucose-dependent insulin secretion (EC50 value 142±20 nM) in isolated rodent islets, and lowered post-prandial glucose in normal rats. AMG-837 exhibits a potential utility for the treatment of type 2 diabetes.
Orally bioavailable partial agonist of GPR40 (FFA1)
Chemical name(S)-3-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)phenyl)hex-4-ynoic acid calcium salt Parent CAS No.[865231-46-5] |
| 產(chǎn)品資料 |
