產(chǎn)品名稱

C-DIM5 - DIM-C-pPhOCH3

產(chǎn)品貨號

Axon 2828 CAS [33985-68-1] MF C24H20N2OMW 352.43 Purity: 99% Soluble in DMSO Description C-DIM5?is a Nur77 agonist. Activation of the orphan nuclear receptor Nur77 by?C-DIM5 is associated with decreased cancer cell survival, induction of apoptosis, induced expression of the apoptosis gene/protein TRAIL, and inhibited tumor growth in vivo.?C-DIM5 induces G0-G1–phase to S-phase arrest in Panc1 cells, and this is accompanied by Nur77-dependent induction of the cyclin-dependent kinase inhibitor p21. KEYWORDS: C-DIM5 | supplier | Nur77 agonist | DIM-C-pPhOCH3 | CDIM5 | CAS [33985-68-1] | Intracellular Transcription Factors | Nurr | Agonist | Receptors | TRAIL

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現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

C-DIM5 - DIM-C-pPhOCH3

Based on 25 reference(s) in Google Scholar 8 10 25

Axon 2828

CAS [33985-68-1]

MF C24H20N2O
MW 352.43

Purity: 99%
Soluble in DMSO

C-DIM5

Description

C-DIM5?is a Nur77 agonist. Activation of the orphan nuclear receptor Nur77 by?C-DIM5 is associated with decreased cancer cell survival, induction of apoptosis, induced expression of the apoptosis gene/protein TRAIL, and inhibited tumor growth in vivo.?C-DIM5 induces G0-G1–phase to S-phase arrest in Panc1 cells, and this is accompanied by Nur77-dependent induction of the cyclin-dependent kinase inhibitor p21.

S Chintharlapalli et al. Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J Biol Chem. 2005 Jul 1;280(26):24903-14.

SO Lee et al. p21 expression is induced by activation of nuclear nerve growth factor-induced Balpha (Nur77) in pancreatic cancer cells. Mol Cancer Res. 2009 Jul;7(7):1169-78.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Nurr NR4A1

Nur77 agonist

Chemical name

3,3'-((4-Methoxyphenyl)methylene)bis(1H-indole)

Parent CAS No.

[33985-68-1]

產(chǎn)品資料