產(chǎn)品說明
細胞 在兩個平行表面之間被均勻地限制/壓縮到具有亞微米分辨率的定義微米高度。
提供不同的限制高度（例如 1 ?m – 300 ?m）
允許進行長期細胞培養(yǎng)和細胞增殖，同時保持對限制的完美控制
與高分辨率光學顯微鏡系統(tǒng)兼容
可以處理足夠多的細胞以進行quan基因表達分析
可與生物功能化微結(jié)構(gòu)基材和/或不同基質(zhì)（幾何控制）結(jié)合
可與凝膠結(jié)合使用（硬度控制）
兼容的 35 毫米培養(yǎng)皿和 6 孔板
如需定制設計，請聯(lián)系我們
細胞遷移 2.5D、非粘附細胞的遷移和相互作用、細胞擠壓、扁平細胞成像（細胞器以 2D 排列）、超分辨率視頻顯微鏡（細胞器移動較少）、收縮性測定等
HeLa 細胞：不受限制，5 ?m、3 ?m。
核裂變和層流破裂受細胞限制程度的調(diào)節(jié)
細胞響應限制高度而經(jīng)歷表型轉(zhuǎn)變
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A flagellate-to-amoeboid switch in the closest living relatives of animals
Brunet. T., et al., Elife, 2021 Jan 15;10:e61037
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The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior
Venturini. V., et al., Science, 2020, 370, eaba2644
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Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells
Y.-J. Liu, M. Piel., et al., Cell, 2015 160(4), 659-672
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Actin flows induce a universal coupling between cell speed and cell persistence
P. Maiuri, R. Voituriez, et al., Cell, 2015 161(2), 374–386
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Geometric friction directs cell migration
M. Le Berre, M. Piel, et al., Physical Review Letter 2013 111, 198101
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Mitotic rounding alters cell geometry to ensure efficient spindle assembly
O. M. Lancaster, B. Baum, et al., Developmental Cell, 2013 25(3), 270-283
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Fine Control of Nuclear Confinement Identifies a Threshold Deformation leading to Lamina Rupture and Induction of Specific Genes
M. Le Berre, J. Aubertin, M. Piel, Integrative Biology, 2012 4 (11), 1406-1414
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Exploring the Function of Cell Shape and Size during Mitosis
C. Cadart, H. K. Matthews, et al., Developmental Cell, 2014 29(2), 159-169
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Methods for Two-Dimensional Cell Confinement
M. Le Berre, M. Piel, et al., 2014, Micropatterning in Cell Biology Part C, Methods in cell biology, 121, 213-29
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