單層細(xì)胞壓縮力測試系統(tǒng)

型號:cell confiner
聯(lián)系人:李先生
聯(lián)系電話:18618101725
品牌:瑞士four-d

單層細(xì)胞壓縮力刺激系統(tǒng)


細(xì)胞被均勻地限制/壓縮在兩個亞微米分辨率的兩個平行表面之間。

不同的限制高度（例如1um – 300um）

允許長期細(xì)胞培養(yǎng)和細(xì)胞增殖，同時保持對封閉的完美控制

與高分辨率光學(xué)顯微鏡系統(tǒng)兼容

可以處理足夠多的細(xì)胞以進(jìn)行完整的基因表達(dá)分析

可與生物功能化的微結(jié)構(gòu)化底物和/或不同的基質(zhì)（幾何形狀控制）結(jié)合使用

可以與凝膠結(jié)合（硬度控制）

兼容任何細(xì)胞培養(yǎng)底物（培養(yǎng)皿至96孔板）


產(chǎn)品：





應(yīng)用：

Cell migration 2.5D, migration and interaction of non-adhesive cells, cell squeezing, imaging of flat cells (organelles aligned in 2D), super-resolution video-microscopy (organelles move less), contractility assay, etc

Confinement illustration
HeLa cells: not confined, 5 ?m, 3 ?m.

Explore examples of applications


> Cancer invasiveness assay: Quantification of migration behaviors and migration transitions

> Cancer aggressiveness assay: Quantification of contractility of somatic or cancer cells

> Endocytosis assay: Improved observation of events taking place at the membrane

> Exocytosis assay: Improved observation of events taking place at the apical membrane

> Frustrated phagocytosis: Characterization of the mechanism

> Immune system in a well: 2D migration and interaction of non-adherent immune cells

> Immune cells interaction: 2D interaction of non-adherent immune cells

> Mitotic assembly assay: Quantification of mitotic spindle disorders

> Quantitative cell migration assay: Fast and fine analysis of cell migration properties

文獻(xiàn)：

PUBLICATIONS

 

  • Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells
    Y.-J. Liu, M. Piel, Cell, et al., 2015 160(4), 659-672
  • Actin flows induce a universal coupling between cell speed and cell persistence
    P. Maiuri, R. Voituriez, et al., Cell, 2015 161(2), 374–386
  • Geometric friction directs cell migration
    M. Le Berre, M. Piel, et al., Physical Review Letter 2013 111, 198101
  • Mitotic rounding alters cell geometry to ensure efficient spindle assembly
    O. M. Lancaster, B. Baum, et al., Developmental Cell, 2013 25(3), 270-283
  • Fine Control of Nuclear Confinement Identifies a Threshold Deformation leading to Lamina Rupture and Induction of Specific Genes
    M. Le Berre, J. Aubertin, M. Piel, Integrative Biology, 2012 4 (11), 1406-1414
  • Exploring the Function of Cell Shape and Size during Mitosis
    C. Cadart, H. K. Matthews, et al., Developmental Cell, 2014 29(2), 159-169
  • Methods for Two-Dimensional Cell Confinement
    M. Le Berre, M. Piel, et al., 2014, Micropatterning in Cell Biology Part C, Methods in cell biology, 121, 213-29

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