產品名稱 (R,S)-AM 1241 - LKT Labs
產品貨號 A480020
產品價格 現貨詢價，電話：010-67529703
產品規(guī)格 1 mg 5 mg 25 mg
產品品牌 lktlabs
產品概述
產品詳情 (R,S)-AM 1241

Description

AM1241 is a selective cannabinoid receptor 2 (CB2) agonist. It demonstrates activity in multiple pain murine models. AM1241 was used to treat osteopathic carcinoma pain in mice. AM1241 decreased allodynia found in a rodent model, and also decreased thermal hyperalgesia. AM1241 was used in a murine Parkinson’s disease model, where it increased expression of Parkin and PINK1, and also stimulated neurogenesis.

Product Info

Cas No.

444912-48-5

Purity

≥97%

Formula

C22H22IN3O3

Formula Wt.

503.34

Chemical Name

(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone

IUPAC Name

(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone

Synonym

AM1241

Solubility

Soluble in DMSO to 10 mM and in ethanol to 10 mM

Appearance

Yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Blue Ice

Downloads

MSDS

A480020 MSDS PDF

Info Sheet

A480020 Info Sheet PDF

References

Shi J, Cai Q, Zhang J et al. AM1241 alleviates MPTP-induced Parkinsons’s disease and promotes the regeneration of DA neurons in PD mice. Oncotarget. 2017 Jun 29;8(40):67837-67850. PMID: 28978077.

Curto-Reyes V, Llames S, Hidalgo A et al. Spinal and peripheral analgesic effects of the CB2 cannabinoid receptor agonist AM1241 in two models of bone cancer-induced pain. Br J Pharmacol. 2010 Jun;160(3):561-73. PMID: 20233215.

Ibrahim MM, Deng H, Zvonok A et al. Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proc Natl Acad Sci USA. 2003 Sep 2;100(18):10529-33. PMID: 12917492.
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