Description
β-Cembrenediol is one of the cembrenediols diterpenes originally found in Anisomeles. These compounds exhibit antibacterial activity against Mycobacterium and antifungal activity against Colletotrichum. Cembrenoids accumulated in tobacco exhibit potent antiproliferative activity and trigger unusual microtubule dynamics in human glioblastoma cells. β-cembrenediol effectively inhibited the root and stem growth of receptor plants and the inhibitory effects was concentration-dependent. Seedlings of lettuce (Tai Yuan Sun) were treated with β-cembrenediol and the results showed that β-cembrenediol significantly inhibited the seedling growth and reduced fresh weight of L. sativa. The compounds effectively affected cell mitotic index and caused cell death.
References
Kulkarni RR, Shurpali K, Gawde RL, et al. Phyllocladane diterpenes from Anisomeles heyneana. J Asian Nat Prod Res. 2012;14(12):1162-8. PMID: 23157282.
Kennedy BS, Nielsen MT, Severson RF. Biorationals from Nicotiana protect cucumbers against Colletotrichum lagenarium (Pass.) ell. & halst disease development. J Chem Ecol. 1995 Feb;21(2):221-31. PMID: 24234021.
Nacoulma AP, Megalizzi V, Pottier LR, De Lorenzi M, Thoret S, et al. Potent Antiproliferative Cembrenoids Accumulate in Tobacco upon Infection with Rhodococcus fascians and Trigger Unusual Microtubule Dynamics in Human Glioblastoma Cells. PLoS ONE 8(10): e77529. doi:10.1371/journal.pone.0077529. PMID: 24167576
Xia RenZhi-qiang YanXiao-feng He, et.al. Allelopathic effect of β-cembrenediol and its mode of action: Induced oxidative stress in lettuce seedlings. Emirates Journal of Food & Agriculture (EJFA) . 2017, 29 , 441-449. DOI: 10.9755/ejfa.2016-09-1263
