This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases.This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein.The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation.Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines.Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.

Target	RPS6KB1
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Tested Applications	ELISA, WB, IHC, FCM
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Purified recombinant fragment of human RPS6KB1 expressed in E. coli.
Purification	Purified antibody
Isotype	IgG1
Conjugation	Unconjugated
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Molecular Weight	59 kDa
Swiss Prot	P23443
GeneID	6198
Gene Symbol	RPS6KB1
OMIM	608938
HGNC	10436
Ensembl	ENSG00000108443
Concentration	1.0 mg/ml
Buffer	PBS with 0.05% sodium azide and 0.5% protein stabilizer.
UNSPSC Code	12352203
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.