ERBB2 Antibody (FITC) is a Rabbit Polyclonal antibody conjugated to FITC against ERBB2. ERBB2 is a protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. It is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. It regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

Target	ERBB2
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Tested Applications	ELISA
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Recombinant human Receptor tyrosine-protein kinase erbB-2 protein (153-598AA).
Purity	> 95%
Purification	Protein G.
Form	Liquid
Isotype	IgG
Conjugation	FITC
Storage	Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Swiss Prot	P04626
GeneID	2064
Gene Symbol	ERBB2
OMIM	16487
NCBI Accession	NP_001005862.1 NM_001005862.2
Buffer	0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
UNSPSC Code	12352203
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.