Wnt5a Antibody is a Rabbit Polyclonal antibody against Wnt5a. The Wnt family includes several secreted glycoproteins that play important roles in animal developmentThere are 19 Wnt genes in the human genome that encode functionally distinct Wnt proteinsWnt members bind to the Frizzled family of seven-pass transmembrane proteins and activate several signaling pathwaysThe canonical Wnt/β-catenin pathway also requires a coreceptor from the low-density lipoprotein receptor familyAberrant activation of Wnt signaling pathways is involved in several types of cancersWnt-5a has been shown to signal through the canonical Wnt pathways as well as through non-canonical pathways and is up-regulated in various types of human cancersIn melanoma, Wnt5a is thought to directly affect cell motility and metastasis.

Target	Wnt5a
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Tested Applications	ELISA, WB, IHC
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Purification	Affinity Chromatography.
Form	Liquid
Isotype	IgG
Conjugation	Unconjugated
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Swiss Prot	P41221
GeneID	7474
Gene Symbol	WNT5A
Buffer	PBS, pH7.3, containing 0.02% sodium azide and 50% Glycerol.
UNSPSC Code	12352203
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.