LIN28: lin-28 homolog (C. elegans), also known as CSDD1, ZCCHC1. Entrez Protein NP078950. LIN28 was first discovered in the nematode C. elegans. It is a heterochronic protein in C. elegans involved in the timing of developmental events and choice of stage specific cell fates. LIN28 expression has been found to be regulated post-transcriptionally by miRNAs in both nematodes and mammals. In humans it is expressed in embryonic stem cells and its expression decreases during differentiation. It is negatively regulated by retinoic acid in neuronal differentiation.

Target	LIN28
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Tested Applications	ELISA, WB, IF/ICC
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Purified recombinant fragment of LIN28 (aa93-209) expressed in E. Coli.
Purification	Purified by Protein G affinity chromatography.
Form	Liquid
Isotype	IgG1
Conjugation	Unconjugated
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Molecular Weight	23 kDa
Swiss Prot	Q9H9Z2
GeneID	79727
Gene Symbol	LIN28A
OMIM	611043
HGNC	15986
Ensembl	ENSG00000131914
Concentration	1.0 mg/ml
Buffer	0.01 M Phosphate buffer, pH 7.4 containing 0.03% sodium azide.
UNSPSC Code	12352203
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.