PRCP Antibody is a Rabbit Polyclonal antibody against PRCP. The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Target	PRCP
Reactivity	Rat
Host	Rabbit
Clonality	Polyclonal
Tested Applications	WB
Recommended dilutions	WB: 1/1000 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Recombinant protein of human PRCP.
Purification	Affinity purified.
Form	Liquid
Isotype	IgG
Conjugation	Unconjugated
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Molecular Weight	Calculated MW: 55 kDa/58 kDa Observed MW: 58 kDa
Swiss Prot	P42785
GeneID	5547
Gene Symbol	PRCP
Concentration	> 1 mg/ml
Buffer	PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
UNSPSC Code	12352203
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.