Phospho-Catenin beta (Tyr489) Antibody detects endogenous levels of Catenin beta only when phosphorylated at Tyrosine 489. Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior.

Target	Catenin beta (pY489)
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Tested Applications	WB
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Purification	Purified by affinity chromatography.
Conjugation	Unconjugated
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Swiss Prot	P35222
GeneID	1499
Gene Symbol	CTNNB1
OMIM	116806
HGNC	2514
Ensembl	ENSG00000168036
Buffer	PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol.
UNSPSC Code	12352203
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.