The DATK32 antibody is specific for a combinatorial epitope of the mouse integrin alpha 4/beta 7 (LPAM-1) heterodimer. LPAM-1 is expressed on most mature lymphocytes and sub-populations of thymocytes and bone marrow cells. It is involved in lymphocyte adhesion and migration and is a receptor for several extracellular matrix proteins including VCAM-1, fibronectin, and MAdCAM-1.

DATK32 is reported to induce LPAM-1 dependent lymphocyte aggregation and block adhesion to VCAM-1, fibronectin, and MAdCAM-1.

Type: Primary
Antigen: LPAM-1
Clonality: Monoclonal
Clone: DATK32
Conjugation: APC (Allophycocyanin)
Epitope:
Host: Rat
Isotype: IgG2a
Reactivity: Mouse