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Description
This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. This antibody is supplied as crude ascites. This ADA antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 287-314 amino acids from the C-terminal region of human ADA.