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Description
LIN7A plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. This LIN7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-207 amino acids from the C-terminal region of human LIN7A.
Immunogen
Human LIN7A.
Other Names
LIN7A; MALS1; VELI1; Protein lin-7 homolog A; Mammalian lin-seven protein 1; Tax interaction protein 33; Vertebrate lin-7 homolog 1; Lin-7A; hLin-7; MALS-1; TIP-33; Veli-1