Recombinant Human Terminal nucleotidyltransferase 4A (TENT4B)
Description
Purity > 85% as determined by SDS-PAGE. MW: 79.3kDa. Full Length: 1-572aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Catalytic subunit of a TRAMP-like complex which has a poly (A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo (A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
PAP-associated domain-containing protein 5; Terminal uridylyltransferase 3; TUTase 3; Topoisomerase-related function protein 4-2; TRF4-2