If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
Rabbit IgG polyclonal antibody for Delta-like protein 1(DLL1) detection. Tested with WB in Human;Mouse;Rat. No cross reactivity with other proteins. DLL1(DELTA-LIKE 1) also known as DL1 or DELTA1, is a protein that in humans is encoded by the DLL1 gene. DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. Using FISH, Gray et al.(1999) mapped the DLL1 gene to chromosome 6q27, near a locus for type I diabetes. Functional analysis by Han et al.(2000) suggested that a soluble fusion protein containing the DSL domain of DLL1 and its adjacent 50 N-terminal amino acids increased the viability of hemopoietic cells but inhibited cell death. Jaleco et al.(2001) used a cell coculture assay to show that DLL1 blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. In contrast, JAG1 did not disturb either B-cell or T-cell/NK-cell development. Galceran et al. found that mouse Lef1 bound multiple sites in the Dll1 promoter in vitro and in vivo, and mutation of the Lef1 sites impaired expression of a reporter transgene in the presomitic mesoderm of embryonic mice.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human DLL1(168-184aa RTDLKYSYRFVCDEHYY), different from the related rat and mouse sequences by one amino acid.
Other Names
Delta-like protein 1;Drosophila Delta homolog 1;Delta1;H-Delta-1;DLL1;UNQ146/PRO172;