A cell-permeable allosteric inhibitor of PAK1 that is non-competitive with respect to ATP binding (IC50 = 2.5 μM); binds covalently to the PAK1 regulatory domain (apparent Kd = 1.9 uM) and prevents binding to the upstream activator Cdc42
Size
25 mg
Concentration
n/a
Applications
n/a
Other Names
1081767-20-5 Pak-1 Pak1 cancers inhibitors signals transduction autoinhibitory kinases allosteric domains PAK1 PAKs 1 one inhibits inhibition P21-activated P21 P-21 P 21 activated IPA3 IPAs 3 three IPA-3 ATP binding binds adenosine 5-triphosphates non-competitive noncompetitive non competitive cdc42 cdc-42 cdcs 42 upstream up-stream up stream serine threonine cells functions blocks activity human upregulated