RSPO1, Recombinant, Human (R-Spondin-1, Roof Plate-specific Spondin, Rspo1)
Description
Purity ~95% (SDS-PAGE). R-Spondin-1 (Rspo-1) belongs to the (Rspo) family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. Rspo-1 is expressed in certain areas of the developing central nervous system, as well as in adrenal glands, ovary, testis, thyroid, and trachea. Rspo can interact with the Frizzled/LRP6 receptor complex in a manner that stimulates the Wnt/beta-catenin signaling pathway. Source: Recombinant protein corresponding to 243aa residues from human RSPO1, expressed in CHO cells. Molecular Weight: ~40kD, SDS-PAGE analysis under reducing conditions. Biological Activity: Enhances BMP-2 mediated differentiation of MC3T3-E1 cells. The expected ED50 is 1-3ug/ml. Endotoxin: <0.1ng/ug of protein (<1EU/ug) AA Sequence: SRGIKGKRQR RISAEGSQAC AKGCELCSEV NGCLKCSPKL FILLERNDIR QVGVCLPSCP PGYFDARNPD MNKCIKCKIE HCEACFSHNF CTKCKEGLYL HKGRCYPACP EGSSAANGTM ECSSPAQCEM