236-297aa; Partial. MW: 10.9kD. Purity >90% as determined by SDS-PAGE. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Size
0.01 mg, 0.05 mg, 0.1 mg, 0.2 mg, 0.5 mg
Concentration
n/a
Applications
n/a
Other Names
[ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD243]
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.Chen C.-J., Chin J.E., Ueda K., Clark D.P., Pastan I., Gottesman M.M., Roninson I.B.Cell 47:381-389(1986) Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.Chen C.-J., Clark D.P., Ueda K., Pastan I., Gottesman M.M., Roninson I.B.J. Biol. Chem. 265:506-514(1990) Multidrug-resistant human sarcoma cells with a mutan