Immunohistochemistry (Paraffin): 1:250, Immunoprecipitation: 5 μg/mL, Western Blot: Assay Dependent
Reviews / Ratings
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Description
beta Catenin Polyclonal Antibody. Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interpla
Immunogen
n/a
Other Names
Cadherin associated protein beta, Catenin beta 1, CATNB, CTNNB