A selective FXR agonist (EC50 = 25 nM) that demonstrates 100-fold increased affinity to FXR compared to endogenous bile acids and 3-fold increased potency compared to the high affinity FXR agonist GW 4064 (EC50 = 80 nM)
Size
10 mg
Concentration
n/a
Applications
n/a
Other Names
farnesoid X receptor FXR nuclear receptor bile acid sensor cholesterol metabolism lipid homeostasis agonist biochemical signal transduction cell organ toxicity dietary fat vitamin endogenous