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Description
NOD2 Monoclonal Antibody (2D9). NOD2 is a member of the apoptosis regulating protein family that includes caspase recruitment-domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). NOD2 plays a role in regulating NF-kappaB, acts as an intracellular receptor for bacterial lipopolysaccharides, and contributes to inflammatory bowel disease (IBD) and Crohn's disease.
Immunogen
n/a
Other Names
NOD-2, NOD 2, CARD15, Caspase recruitment domain protein 15, IBD1, Inflammatory Bowel disease protein 1