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Description
NOD3 Polyclonal Antibody. NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-βB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.
Immunogen
n/a
Other Names
CLR16.2; NOD3; CARD15-like protein; NOD-like receptor C3; caterpiller 16.2; caterpiller protein 16.2; nucleotide-binding oligomerization domain protein 3; nucleotide-binding oligomerization domain; leucine rich repeat and CARD domain containing 3; protein NLRC3