Purity > 90% as determined by SDS-PAGE. MW: 65kDa. Full Length of Mature Protein: 23-480aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Serine protease with a variety of targets, including Extracellular domain matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the Extracellular domain space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
High-temperature requirement A serine peptidase 1; L56; Serine protease 11