A metabolite and degradation product of the pesticide DDT; accumulates in various fish and sediment surrounding a DDT manufacturing plant; inhibits estrogen binding to rtERs (IC50 = 3.2 μM); induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles; induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles; increases degeneration of ovarian follicles and reduces testicular size in Japanese medaka (O. latipes),