Human CellExp? Biotinylated PD-L1, Human Recombinant
Description
Purity ≥95%. The protein is fused with 6xHis tag at the N-terminus, has a calculated MW of 26.4 kDa. The protein migrates as 35 -40 kDa in SDS-PAGE under reducing conditions due to glycosylation. Human Programmed Cell Death 1 Ligand-1 (PD-L1) is also known as CD274 and B7-H1) is a type I transmembrane protein which binds to its receptor, Programmed Cell Death protein 1 (PD-1). PD-L1 is widely distributed on leukocytes, nonhematopoietic cells, and in nonlymphoid tissues including islets. PD-L1 and PD-1 pathway serves as an ``immune checkpoint'' and its blockade is a highly promising therapy for a broad spectrum of cancers.