NEuRL2, 1-285aa, Human, His tag, E.coli (Denatured)
Description
Purity: > 85% by SDS - PAGE Format: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol. NEuRL2 plays an important role in the process of myofiber differentiation and maturation. This protein is probable substrate-recognition component of a SCF-like ECS (Elongin BC-CuL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. It probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, NEuRL2 controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma. Recombinant human NEuRL2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.