PPM1D, 98-375aa, Human, His tag, E.coli (Denatured)
Description
Purity: > 90% by SDS - PAGE Format: Liquid, In 20mM Tris-HCl (pH8.0) containing 10% glycerol. PPM1D also known as Protein phosphatase 1D magnesium-dependent, delta isoform. This protein is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase (MAPK/p38) through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. Recombinant human PPM1D, fused to His-tag at N-terminus, was expressed in E.coli.
Size
250ug, 50ug, 10ug
Concentration
n/a
Applications
SDS-PAGE
Other Names
Protein phosphatase 1D magnesium-dependent delta isoform, Protein phosphatase 1D magnesium-dependent, delta isoform, PP2C-DELTA, WIP1