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Description
Alexa Fluor? 594 anti-ATF7. Activating Transcription Factor 7 (ATF7) is a member of the ATF/cAMP response element-binding protein family. Among these ATF family members, ATF7 shares highly structurally conserved N-terminal activation domain and the C-terminal DNA binding/dimerization domain with ATF2. ATF7 has no intrinsic transcriptional activity and forms functional heterodimers with c-Jun or c-Fos proteins. Upon stimulation, such as pathogen infection and various stresses, ATF7 is phosphorylated by stress-activated protein kinase p38 at Thr51 and Thr53 and in turn resulted in the activation of ATF7 target genes. In the absence of stress, ATF silences targets genes by recruiting histone methyltransferases, leading to the formation of heterochromatin. ATF7 deficient mice die soon after birth. Double knockout mutations of ATF2 and ATF7 lead to prenatal lethality with abnormalities in liver and heart.