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Description
Purified anti-Aurora B. Aurora B, also known as AURKB, is a member of the Aurora family of Serine/Threonine protein kinases. The expression level of Aurora B is dramatically increased during the S/G2/M phases of the cell cycle. Aurora B plays a critical role in cell division and chromosome-microtubule interactions during mitosis. Aurora B forms the chromosomal passenger complex (CPC) together with INCENP, Survivin, and Borealin and functions to ensure faithful chromosome segregation. The CPC localizes to the kinetochores from prophase to metaphase and migrates to the central spindle and the midbody during telophase. Aurora B phosphorylates Histone H3 at residues Serine 53 and Serine 28 during prophase, leading to the dissociation of HP1 from chromatin and condensation of chromosome. Aurora B was found to be overexpressed in several malignant cancers and is involved in promoting tumor development and progression.
Immunogen
Human Aurora B recombinant protein (1-150 a.a.) expressed in E. coli.
Other Names
Aurora kinase B, AURKB, Aurora 1, Aurora- and IPL1-like midbody-associated protein 1 (AIM-1), Aurora/IPL1-related kinase 2 (ARK-2), STK-1