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Description
PE anti-human APCDD1 (DRAPC1). APCDD1 (adenomatosis polyposis coli down-regulated 1), also known as B7323, DRAPC1, or FP7019, is a 514 amino acid single-pass type I membrane protein. APCDD1 is expressed in the gastrointestinal tract, placental trophoblasts, and both epidermal and dermal compartments from human hair follicles. It is also weakly expressed in lymphoid tissues. APCDD1 has been reported to be directly regulated by the beta-catenin/ITF-2 complex and that its elevated expression promotes the proliferation of colonic epithelial cells. It is thought to function as a developmental target of the beta-catenin pathway and may play an important role in colorectal tumorigenesis. Recently, it was found to negatively regulate Wnt signaling in a cell-autonomous manner.