If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
Go-ChIP-Grade? Purified anti-Bcl11b. BCL11B is a C2H2-type zinc finger protein and is closely related to BCL11A whose translocation may be associated with B-cell malignancies. BCL11B is expressed in thymus, mainly T cells. It is indispensable for T lineage development. When BCL11B was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cells in vitro, and effectively prevented tumor metastasis in vivo. Therefore, ITNKs may represent a new cell source for cell-based therapies. BCL11B is also known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Recent research suggests that BCL11B is crucial for ameloblasts (the cells that produce tooth enamel) to form and work properly.