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Description
Purified anti-Bcl-XS/L. Bcl-X belongs to Bcl-2 family, and has several alternative splicing isoforms. It plays a critical role in control of apoptosis. The large isoform Bcl-XL (26kD) contains the highly conserved BH1/BH2 domain and protects cells from apoptosis, whereas the short isoform, Bcl-XS (19kD), which lacks of conserved BH1/BH2 domain, promotes apoptosis by interacting with Bcl-XL and Bcl-2. Bcl-XS is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-XL is found in long-lived, post-mitotic cells, such as adult brain.
Immunogen
Bcl-XS/L (3-14 amino acid, conserved in both human and mouse)