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Description
Purified anti-CD105 (Endoglin). CD105 (Endoglin) is expressed by endothelial cells, pro-fibrogenic cells and hepatic stellate cells; it plays important roles in endothelial proliferation and cardiovascular development. Mutations in the ENG gene lead to Hereditary Hemorrhagic Telangiectasia, a disorder characterized by arteriovenous malformations. An extracellular domain of the full-length membrane endoglin, soluble endoglin, is a proposed biomarker of cardiovascular disease progression, cardiovascular disease treatment and endothelial dysfunction. Endoglin is also expressed in the syncytiotrophoblast throughout pregnancy, but transiently upregulated in the extravillous trophoblast of anchoring villi. Furthermore, endoglin is overexpressed in the tumor-associated vascular endothelium, where it modulates angiogenesis.
Immunogen
Full length recombinant protein of human Endoglin/CD105 expressed in HEK293T.