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Description
Purified anti-CAMK IV. Calcium/calmodulin-dependent protein kinase IV (CaMK IV) is a multifunctional serine/threonine kinase regulating different cellular processes. CaMK IV resides in both the nucleus and cytosol, but the active phosphorylated form of CaMK IV is predominantly nuclear. Once activated, CAMK IV enhances BCL2 gene expression. CaMK IV also actively regulates gene transcription by phosphorylating HDAC4. Phosphorylation of HDAC4 by CaMK IV promotes HDAC4 nuclear exports in neurons, resulting in major cell death mechanism in cerebral ischemia. CaMK IV–mTOR-dependent autophagy was fundamentally important for IL-6 production in vitro and in vivo.CaMK IV is abnormally increased in T cells from patients with SLE and lupus-prone mice. Genetic or pharmacologic inhibition of CaMK IV resulted in a significant decrease of autoantibody production, mesangial cell proliferation, improved Treg function, improvement of lupus-related pathology, and the survival rates. CaMK IV inhibition has potential as a therapeutic strategy for Th17-driven autoimmune diseases.
Immunogen
Purified recombinant fragment of human CAMK4 (AA:35-292) expressed in E. coli.
Other Names
Calcium/calmodulin-dependent protein kinase type IV, CaM kinase-GR, CAMK4