Purity ~95% (SDS-PAGE). The glycolytic enzyme enolase (2-phospho-Dglycerate hydrolyase) exists as several dimeric isoenzymes (aa, ab, ag, bb and gg) composed of three distinct subunits: a, b, and g (alpha, beta, and gamma). Three isoenzymes are found in human brain: aa, ag, and gg. The ag and gg-enoloase isoenzymes are also known as neuron- specific enolase (NSE) as these isoenzymes initially were detected in neurons and neuronendocrine cells. Lung cancer is one of the most spread cancer forms with incidences about 50-100 per 100,000 population. Approximately 20% of the lung cancer is small cell lung cancer. NSE has been shown to be a valuable tumor marker of neuroendocrine origin, particulary in small cell lung cancer and in neuroblastoma. Patients with small cell lung cancer show various proportions of ag and gg isoenzymes. The determination of NSE should detect ag and gg isoforms with the same sensitivity. The antibodies for this particular assay are specific for the g-subunit witho
Size
100ug
Concentration
n/a
Applications
DB ELISA IHC WB
Other Names
Neuron Specific Enolase, Recombinant, Human (NSE, Gamma-enolase, 2-phospho-D-glycerate hydro-lyase, Neural Enolase, Enolase 2, ENO2)