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Description
Biotin anti-mouse CCL11 (Eotaxin). CCL11, also known as Eotaxin, is a small cytokine belonging to the CC chemokine family. The full length of CCL11 is 97 amino acids (a.a.) with a 23 a.a. signal peptide, which is cleaved to generate a 74 a.a. mature protein. The molecular mass of CCL11 is about 10 kD, and its gene is located on the q arm of chromosome 17. CCL11 expression has been found in normal tissues such as smooth muscle and small intestine. Endothelial cells, smooth muscle cells, epithelial cells, alveolar macrophages, and eosinophils are known to produce CCL11. Mouse CCL11 shares a 61% and 96% amino acid sequence identity to both human and rat, respectively. CCL11 is produced when inflammatory cytokines, such as IL-5 and TNF-α, stimulate lung endothelial cells, fibroblasts, and smooth muscle cells in response to allergens. As a potent eosinophil chemoattractant, via binding to its major receptor, CCR3, CCL11 efficiently induces the accumulation of eosinophils, a response associated with allergic inflammation. Therefore, atopic dermatitis, asthma, and parasitic infections are a few of the eosinophilic inflammatory diseases directly related to CCL11. In addition, CCL11 induces the formation of blood vessels and other angiogenic responses which are accompanied by inflammatory infiltration; it has been shown to regulate tumor development.
Immunogen
Recombinant mouse CCL11
Other Names
Eotaxin, Eotaxin-1, small inducible cytokine subfamily A, member 11 (SCYA11)