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Description
Rabbit IgG polyclonal Picoband? antibody for ch TOG/CKAP5 detection. Tested with WB, IHC-P, ICC/IF, Direct ELISA in Human;Mouse;Rat. No cross reactivity with other proteins. Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the CKAP5 gene. It is mapped to 11p11.2. This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacternatively spliced transcript variants encoding different isoforms have been identified.
Immunogen
E.coli-derived human ch TOG/CKAP5 recombinant protein (Position: M1-L221).
Other Names
Cytoskeleton-associated protein 5; Colonic and hepatic tumor overexpressed gene protein; Ch-TOG; CKAP5; KIAA0097