Neuronal Specific Enolase (NSE), Recombinant, Human
Description
Purity ≥95% (SDS-PAGE). Recombinant NSE comprises a 433 amino acid fragment (2-434) corresponding to processed mature NSE protein and is expressed in E. coli with an amino- terminal hexahistidine tag. NSE is an isoform of the glycolytic enzyme enolase and is expressed primarily in neurons, in normal and neoplastic neuroendocrine cells. NSE is a highly soluble cytoplasmic protein that is readily secreted into the CSF and serum following tissue damage. NSE shows neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons and binds in a calcium-dependent manner to cultured neocortical neurons promoting cell survival. Applications: Suitable for use in ELISA.