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Description
Purified anti-IκB-α. IκB-α is an inhibitory protein that binds to the NF-κB complex and retains this complex in the cytoplasm where it cannot activate transcription. Upon cellular stimulation, the IκB proteins are phosphorylated and degraded via the ubiquitin pathway allowing for nuclear translocation of NF-κB. The NF-κB complex can then bind DNA to activate gene expression of multiple proteins involved in inflammation, cellular proliferation, differentiation, and apoptosis.
Immunogen
Mouse IkB-α recombinant protein (full length) expressed in E. coli.
Other Names
Nuclear factor of kappa light chain enhancer in B cells-inhibitor alpha, IKBA, IκBα