A potent CB1 receptor antagonist (IC50 = 118.9 pM; Ki = 27.2 pM for rat CB1); selective for CB1 over CB2, exhibiting only 46% inhibition of CB2 at a concentration of 10 μM; reverses (+)-WIN 55,212-2 inhibition of forskolin-induced cAMP accumulation in a dose-dependent manner in CHO cells expressing human CB1; reduces food intake and body weight gain in a rat model of diet-induced obesity at a dose of 40 mg/kg; reduces body weight gain and white adipose accumulation in a mouse model of early onset diet-induced obesity