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Description
Purified anti-PADI4. PADI4 is an enzyme that catalyzes peptidyl arginine to citrulline in the presence of Ca2+ ions. This reaction, known as citrullination, leads to the post-translational modification of proteins. PADI4 was initially cloned from the HL-60 cell line (human promyelocytic leukemia cells). It is mainly expressed in granulocytes, monocytes and CD34+ stem cells. PADI4 may play a role in granulocyte and macrophage development leading to inflammation and immune response. The PADI4 single-nucleotide polymorphism (SNP) and haplotypes were associated with rheumatoid arthritis susceptibility. Recently, PADI4 has also been found in a variety of malignant tumors and implies its potential roles in tumorigenesis.
Immunogen
Full length recombinant protein of human PADI4 expressed in HEK293T.
Other Names
Peptidylarginine deiminase 4, Peptidyl Arginine Deiminase, Type IV, PADI5, HL-60 PAD, Protein-Arginine Deiminase Type-4, PAD4