Pin 1, Recombinant, Human (Peptidyl-prolyl cis/trans Isomerase NIMA-interacting 1)
Description
Purity ≥ 95% by SDS PAGE. Synonyms: NIMA-interacting Protein 1 Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA ,PLK I, Wee, and Myt1 kinases), several transcription factors like beta-Catenin, c-Jun, and the tumor suppressor protein p53, and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1. Sequence: MADEEKLPPG/ WEKRMSRSSG/ RVYYFNHITN/ ASQWERPSGN/ SSSGGKNGQG/ EPARVRCSHL/ LVKHSQSRRP/ SSWRQEKITR/ TKEEALELIN/ GYIQKIKSGE/