Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9) (aa 650-700)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
mouse
Isotype
n/a
Format
serum
Size
100 μL
Concentration
n/a
Applications
Immunohistochemistry (IHC),Western Blotting (WB)
Reviews / Ratings
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Description
Function: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.Subcellular location: Secreted ?? extracellular space ?? extracellular matrixTissue specificity: Produced by normal alveolar macrophages and granulocytes. MMP9 is constitutively expressed by some tumor cell lines including U937, HT1080, HL60 but not by most quiescent cells and tissues. Also known as: Matrix Metalloproteinase-9, MMP-9, 92 kDa gelatinase, 92 kDa type IV collagenase, Gelatinase B, CLG4B.
Immunogen
A synthetic peptide from aa region 650-700 of mouse MMP9 conjugated to blue carrier protein was used as the antigen.