PIN2/TERF1 Interacting, Telomerase Inhibitor 1 (PINX1) (AA 1-328) protein
Description
Recombinant Human PIN2/TERF1-Interacting Telomerase Inhibitor 1/PINX1 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Lys328) of Human PINX1 fused with a 6His tag at the N-terminus. PIN2/TERF1-Interacting Telomerase Inhibitor 1 (PINX1) belongs to the PINX1 family . PINX1 contains a G-patch domain and a Telomerase Inhibiting Domain that is capable of binding MCRS1, TERT and TERF1. PINX1 is a widely expressed protein that localizes to nucleoli and telomere speckles. PINX1 can mediate TRF1 and TERT accumulation in nucleolus and enhance TRF1 binding to telomeres. PINX1 is recruited to chromosome periphery by Nucleolin, the complex is necessary for faithful chromosome congression. In addition, PINX1 may inhibit cell proliferation and act as tumor suppressor.