產(chǎn)品名稱 PRT4165 from LIFESPAN BIOSCIENCES INC.
    產(chǎn)品貨號 LS-H14818
    產(chǎn)品價(jià)格 現(xiàn)貨詢價(jià)，電話：010-67529703
    產(chǎn)品規(guī)格 n/a
    產(chǎn)品品牌 LIFESPAN BIOSCIENCES INC.
    產(chǎn)品概述
    產(chǎn)品詳情
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    Product NamePRT4165
    DescriptionPurity >98% by NMR, TLC. PRT-4165 is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50 = 3.9 uM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2a. PRT-4165 inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo and as such represents a new tool for studying chromatin remodeling.
    Sizen/a
    Concentrationn/a
    Applicationsn/a
    Other Names2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione
    Gene, Accession, CAS #CAS: 31083-55-3
    Catalog #LS-H14818
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    Order / More InfoPRT4165 from LIFESPAN BIOSCIENCES INC.
    Product Specific Referencesn/a
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